PNU-142586

PNU-142586 is the major metabolite of Linezolid (HY-10394) . PNU-142586 can inhibit the activity of DNA topoisomerase 2-α (TOP2A) and DNA topoisomerase 2-β (TOP2B) . PNU-142586 interferes with DNA replication and transcription by blocking the binding of DNA to TOP2 and inhibiting ATP hydrolysis. PNU-142586 can be used to study Linezolid-induced hematotoxicity and its molecular mechanism[1].

Product Specifications

CAS Number

[368891-70-7]

UNSPSC

12352005

Target

Topoisomerase

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Smiles

O=C(CN(CCO)C1=CC=C(C=C1F)N2C(O[C@H](C2)CNC(C)=O)=O)O

Molecular Formula

C16H20FN3O6

Molecular Weight

369.34

References & Citations

[1]Thu VTA, et al. Deciphering linezolid-induced hematologic toxicity: Targeting TOP2A and TOP2B via its primary metabolite PNU142586. Sci Adv. 2025 May 30;11 (22) :eadt5833.