FUB 349

FUB 349 (Compound 8) is a selective Aromatase inhibitor with an IC50 of 12 μM. FUB 349 is also a H3 receptor antagonist with Kis of 12 and 2.1 nM for rH3R and hH3R, respectively. FUB 349 can be used for neurological diseases such as cognitive impairment research[1][2].

Product Specifications

CAS Number

[184023-52-7]

UNSPSC

12352005

Target

Cytochrome P450; Histamine Receptor

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

C1(CCCCC2=CC=CC=C2)=CN=CN1

Molecular Formula

C13H16N2

Molecular Weight

200.28

References & Citations

[1]Karjalainen A, et al. Synthesis of new potent and selective aromatase inhibitors based on long-chained diarylalkylimidazole and diarylalkyltriazole molecule skeletons. Eur J Pharm Sci. 2000 Aug;11 (2) :109-31. |[2]Ligneau X, et al. Distinct pharmacology of rat and human histamine H (3) receptors: role of two amino acids in the third transmembrane domain. Br J Pharmacol. 2000 Dec;131 (7) :1247-50.