SU11606
SU11606 is a Met inhibitor, with an average IC50 of 0.17 μM. SU11606 shows inhibitory activity on Ron, FLK-1, with IC50s of 2.5 μM and 0.18 μM, respectively. SU11606 can be used in the research of tumors[1].
Product Specifications
CAS Number
669764-17-4
UNSPSC
12352005
Target
C-Met/HGFR; VEGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=S(C1=CC2=C(C=C1)NC(/C2=C\C3=C(C(CCCN4CCOCC4)=C(N3)C)C)=O)(N(C)C5=CC=CC(Cl)=C5)=O
Molecular Formula
C29H33ClN4O4S
Molecular Weight
569.11
References & Citations
[1]Wang X, et al. Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion. Mol Cancer Ther. 2003 Nov;2 (11) :1085-92.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
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