SU11606

SU11606 is a Met inhibitor, with an average IC50 of 0.17 μM. SU11606 shows inhibitory activity on Ron, FLK-1, with IC50s of 2.5 μM and 0.18 μM, respectively. SU11606 can be used in the research of tumors[1].

Product Specifications

CAS Number

[669764-17-4]

UNSPSC

12352005

Target

C-Met/HGFR; VEGFR

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=S(C1=CC2=C(C=C1)NC(/C2=C\C3=C(C(CCCN4CCOCC4)=C(N3)C)C)=O)(N(C)C5=CC=CC(Cl)=C5)=O

Molecular Formula

C29H33ClN4O4S

Molecular Weight

569.11

References & Citations

[1]Wang X, et al. Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion. Mol Cancer Ther. 2003 Nov;2 (11) :1085-92.