IVL 745

IVL 745 (XRP 1745A) is a very late antigen 4 (VLA-4, integrin α4β1) antagonist. IVL 745 reduces the airway inflammatory response of sensitized rats and sheep. IVL 745 can be used for airway inflammation and asthma research[1].

Product Specifications

CAS Number

[229627-58-1]

Product Name Alternative

XRP 1745A

UNSPSC

12352005

Target

Integrin

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C(CCN(CC1=CC=C(C(OC)=C1)OC)C(CNC(CC2=CC=C(C(OC)=C2)NC(NC3=CC=CC=C3C)=O)=O)=O)O

Molecular Formula

C31H36N4O8

Molecular Weight

592.64

References & Citations

[1]Norris V, et al. Effect of IVL745, a VLA-4 antagonist, on allergen-induced bronchoconstriction in patients with asthma. J Allergy Clin Immunol. 2005 Oct;116 (4) :761-7.