IVL 745
IVL 745 (XRP 1745A) is a very late antigen 4 (VLA-4, integrin α4β1) antagonist. IVL 745 reduces the airway inflammatory response of sensitized rats and sheep. IVL 745 can be used for airway inflammation and asthma research[1].
Product Specifications
CAS Number
229627-58-1
Product Name Alternative
XRP 1745A
UNSPSC
12352005
Target
Integrin
Related Pathways
Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(CCN(CC1=CC=C(C(OC)=C1)OC)C(CNC(CC2=CC=C(C(OC)=C2)NC(NC3=CC=CC=C3C)=O)=O)=O)O
Molecular Formula
C31H36N4O8
Molecular Weight
592.64
References & Citations
[1]Norris V, et al. Effect of IVL745, a VLA-4 antagonist, on allergen-induced bronchoconstriction in patients with asthma. J Allergy Clin Immunol. 2005 Oct;116 (4) :761-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α4β1
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