N-Oxalylglycine (Standard)
N-Oxalylglycine (Standard) is the analytical standard of N-Oxalylglycine. This product is intended for research and analytical applications. N-Oxalylglycine (N-Oxaloglycine) is a Jumonji C-domain-containing histone lysine demethylase inhibitor. N-Oxalylglycine inhibits JMJD2A, JMJD2C and JMJD2D. N-Oxalylglycine also inhibits HIF prolylhydroxylase domain-1 (PHD-1) and PHD-2, with an IC50 of 2.1 μM and 5.6 μM, respectively[1][2].
Product Specifications
CAS Number
5262-39-5
UNSPSC
12352100
Target
HIF/HIF Prolyl-Hydroxylase; Histone Demethylase; Reference Standards
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C(O)CNC(C(O)=O)=O
Molecular Formula
C4H5NO5
Molecular Weight
147.09
References & Citations
[1]Hamada S, et al. Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors. Bioorg Med Chem Lett. 2009 May 15;19 (10) :2852-5. |[2]Hamada S, et al. Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors. J Med Chem. 2010 Aug 12;53 (15) :5629-38.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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