Tetrahydromethotrexate
Tetrahydromethotrexate is a more potent folate antagonist than Methotrexate (HY-14519) in studies against certain bacteria (Streptococcus faecalis, Pediococcus erevisiae) and in animal models. Tetrahydromethotrexate is used in the research of cancer and autoimmune diseases[1].
Product Specifications
CAS Number
[4299-28-9]
UNSPSC
12352005
Target
Antifolate; Bacterial; DNA/RNA Synthesis
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(CC[C@H](NC(C1=CC=C(C=C1)N(C)CC2NC3=C(N=C(N=C3NC2)N)N)=O)C(O)=O)O
Molecular Formula
C20H26N8O5
Molecular Weight
458.47
References & Citations
[1]Horwitz SB, et al. Reduced derivatives of methotrexate. J Med Chem. 1968 Jul;11 (4) :907-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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