Q-VD-OPh (GMP)
Q-VD-OPh (GMP) is Q-VD-OPh produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 7 with an IC50 of 48 nM and 25-400 nM for other caspases including caspase 1, 3, 8, 9, 10, and 12. Q-VD-OPh can inhibits HIV infection. Q-VD-OPh is able to cross the blood-brain barrier.
Product Specifications
CAS Number
1135695-98-5
UNSPSC
12352005
Target
Caspase; HIV
Related Pathways
Anti-infection; Apoptosis
Field of Research
Cancer; Infection
Smiles
O=C(O)C[C@H](NC([C@@H](NC(C1=NC2=CC=CC=C2C=C1)=O)C(C)C)=O)C(COC3=C(F)C=CC=C3F)=O
Molecular Formula
C26H25F2N3O6
Molecular Weight
513.49
References & Citations
[1]Laforge M, et al. The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques. J Clin Invest. 2018 Apr 2;128 (4) :1627-1640.
Shipping Conditions
Room temperature
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported
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