Adenosine dialdehyde (Standard)

Adenosine dialdehyde (Standard) is the analytical standard of Adenosine dialdehyde. This product is intended for research and analytical applications. Adenosine dialdehyde, a purine nucleoside analogue, is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM) [1]. Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo and can be used for the cancer research[1][2].

Product Specifications

CAS Number

[34240-05-6]

UNSPSC

12352100

Target

Nucleoside Antimetabolite/Analog; Reference Standards; S-adenosylhomocysteine hydrolase (SAHH)

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Smiles

O=CC(OC(C=O)CO)N1C=NC2=C(N)N=CN=C12

Molecular Formula

C10H11N5O4

Molecular Weight

265.23

References & Citations

[1]G V Madhavan, et al. Synthesis and antiviral evaluation of 6'-substituted aristeromycins: potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolase. J Med Chem|[2]B Bostrom, et al. Inhibitory effect of adenosine dialdehyde on in situ murine neuroblastoma growth.Cancer Res. 1988 Nov 1;48 (21) :5933-6.|[3]V Ramakrishnan, et al. Adenosine dialdehyde and neplanocin A: Potent inhibitors of S-adenosylhomocysteine hydrolase in neuroblastoma N2a cells. Neurochem Int. 1987;10 (4) :423-31.