PEAQX (tetrasodium hydrate)

PEAQX tetrasodium hydrate (NVP-AAM077 tetrasodium hydrate) is a tetrasodium hydrate of PEAQX (HY-12294) . PEAQX tetrasodium hydrate is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX tetrasodium hydrate can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures[1][2].

Product Specifications

Product Name Alternative

NVP-AAM077 (tetrasodium hydrate)

UNSPSC

12352005

Target

Apoptosis; Caspase; iGluR

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Purity

98.0

Solubility

H2O : ≥ 25 mg/mL

Smiles

BrC1=CC=C([C@H](C)NC(P(O[Na])(O[Na])=O)C2=CC=CC3=C2N=C(O[Na])C(O[Na])=N3)C=C1.[H]O[H]

Molecular Formula

C17H15BrN3Na4O6P

Molecular Weight

560.15

References & Citations

[1]Auberson YP, et al. 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett. 2002 Apr 8;12 (7) :1099-102.|[2]Anastasio NC, et al. Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. Neuroscience. 2009 Nov 10;163 (4) :1181-91.|[3]Qian Xu, et al. Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor. J Neurol Sci. 2017 May 15;376:166-175.