Moracin M (Standard)

Moracin M (Standard) is the analytical standard of Moracin M. This product is intended for research and analytical applications. Moracin M is a phenolic component that can be isolated from Mori Cortex, is a potent phosphodiesterase-4 (PDE4) inhibitor with IC50 values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity[1][2].

Product Specifications

CAS Number

[56317-21-6]

UNSPSC

12352100

Target

Autophagy; Endogenous Metabolite; NF-κB; Phosphodiesterase (PDE) ; Reference Standards

Related Pathways

Autophagy; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Inflammation/Immunology

Smiles

OC1=CC(C2=CC3=CC=C(O)C=C3O2)=CC(O)=C1

Molecular Formula

C14H10O4

Molecular Weight

242.23

References & Citations

[1]Chen SK, et al. Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor. Bioorg Med Chem Lett. 2012 May 1;22 (9) :3261-4.|[2]Lee JH, et al. Moracin M inhibits airway inflammation by interrupting the JNK/c-Jun and NF-κB pathways in vitro and in vivo. Eur J Pharmacol. 2016;783:64-72.|[3]Guo F, et al. Moracin M inhibits lipopolysaccharide-induced inflammatory responses in nucleus pulposus cells via regulating PI3K/Akt/mTOR phosphorylation. Int Immunopharmacol. 2018 May;58:80-86.