Ch-319
Ch-319 is a Triphenyltin (IV) carboxylate derivative. Ch-319 reduces androgen receptor expression, AKT and PRAS40 phosphorylation levels, and increases FOXO3a expression. Ch-319 increases Apoptosis. Ch-319 can be used in the research of prostate cancer[1].
Product Specifications
CAS Number
[2589088-07-1]
UNSPSC
12352005
Target
Akt; Androgen Receptor; Apoptosis; Drug Derivative
Related Pathways
Apoptosis; Others; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
O=C(O[Sn](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4C(NCC5=CC=CC=C5)=O
Molecular Formula
C33H27NO3Sn
Molecular Weight
604.28
References & Citations
[1]Waseem D, et al. Triphenylstannyl 2- (benzylcarbamoyl) benzoate (Ch-319) modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer. Cancer Research, 2018, 78 (13_Supplement) : 688-688.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122894/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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