Ch-319

Ch-319 is a Triphenyltin (IV) carboxylate derivative. Ch-319 reduces androgen receptor expression, AKT and PRAS40 phosphorylation levels, and increases FOXO3a expression. Ch-319 increases Apoptosis. Ch-319 can be used in the research of prostate cancer[1].

Product Specifications

CAS Number

[2589088-07-1]

UNSPSC

12352005

Target

Akt; Androgen Receptor; Apoptosis; Drug Derivative

Related Pathways

Apoptosis; Others; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Smiles

O=C(O[Sn](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4C(NCC5=CC=CC=C5)=O

Molecular Formula

C33H27NO3Sn

Molecular Weight

604.28

References & Citations

[1]Waseem D, et al. Triphenylstannyl 2- (benzylcarbamoyl) benzoate (Ch-319) modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer. Cancer Research, 2018, 78 (13_Supplement) : 688-688.