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(E/Z) -HOIPIN-1

(E/Z) -HOIPIN-1 ((E/Z) -JTP-0819958) is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 value >2.8 μM. HOIPIN-1 inhibits LUBAC-mediated NF-kB activation.

Product Specifications

CAS Number

2470242-33-0

Product Name Alternative

(E/Z) -JTP-0819958

UNSPSC

12352005

Target

IKK

Related Pathways

NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(O[Na])C1=C(/C=C/C(C2=C(OC)C=CC=C2)=O)C=CC=C1

Molecular Formula

C17H13NaO4

Molecular Weight

304.27

References & Citations

[1]Katsuya K, et al. Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling. Biochem Biophys Res Commun. 2019 Feb 12;509 (3) :700-706.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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