CHMFL-KIT-031
CHMFL-KIT-031 is a highly selective KIT V559D inhibitor, with an IC50 of 28 nM. CHMFL-KIT-031 potently affects KIT V559D mutant’s phosphorylation at Y703/719/823 sites. CHMFL-KIT-031 inhibits the tumor growth in BaF3-TEL-KIT-V559D cell inoculated mouse model[1].
Product Specifications
UNSPSC
12352005
Target
C-Kit
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(NCC(NC1=CC2=C(C=C1)C(/C=C/C3=NC=CC=C3)=NN2)=O)C4=CC(OC)=C(OC)C(OC)=C4
Molecular Formula
C26H25N5O5
Molecular Weight
487.51
References & Citations
[1]Yu K, et al. Discovery of a highly selective KIT kinase primary V559D mutant inhibitor for gastrointestinal stromal tumors (GISTs) . Oncotarget. 2017 Nov 15;8 (67) :111110-111118.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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