DDR1/2 inhibitor-3
DDR1/2 inhibitor-3 (5n) is a DDR1/2 inhibitor, with IC50 valuesof 9.4 and 20.4 nM, respectively. DDR1/2 inhibitor-3 can be used in anti-inflammatory research[1].
Product Specifications
CAS Number
[2241813-33-0]
UNSPSC
12352005
Target
Discoidin Domain Receptor
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology
Smiles
O=C(NC1=CC(C(F)(F)F)=CC(CN2CCN(C)CC2)=C1)C3=CC=C(C(C)C)C(C#CC4=CN=C5C=NC=CN54)=C3
Molecular Formula
C31H31F3N6O
Molecular Weight
560.61
References & Citations
[1]Wang Z, et al. Design, Synthesis, and Biological Evaluation of 3- (Imidazo[1,2- a]pyrazin-3-ylethynyl) -4-isopropyl- N- (3- ((4-methylpiperazin-1-yl) methyl) -5- (trifluoromethyl) phenyl) benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2. J Med Chem. 2018 Sep 13;61 (17) :7977-7990.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DDR1; DDR2
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