GSK699
GSK699 is a PCAF/GCN5 PROTAC degrader. GSK699 promotes the ubiquitination and degradation of PCAF/GCN5. GSK699 inhibits the production of cytokines/chemokines (e.g., IL-6, CXCL1/GROα). GSK699 can be used in the research of inflammatory diseases (target protein ligand: HY-101027, CRBN ligand: HY-103596)[2].
Product Specifications
CAS Number
2260944-68-9
UNSPSC
12352005
Target
CXCR; Histone Acetyltransferase; Interleukin Related
Related Pathways
Epigenetics; GPCR/G Protein; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O=C(N(CCCN(C1=CC=C(CCCOC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)C=C1)C)C)C5=CC=C([C@@H]6CN(C)C[C@H](NC(C=NN7C)=C(Br)C7=O)C6)C=C5
Molecular Formula
C45H51BrN8O7
Molecular Weight
895.84
References & Citations
[1]Bassi ZI, et al. Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach. ACS Chem Biol. 2018 Oct 19;13 (10) :2862-2867. |[2]Luo H, et al. Advancing Design Strategy of PROTACs for Cancer Therapy. MedComm (2020) . 2025 Jun 25;6 (7) :e70258.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GCN5/PCAF; IL-6
Frequently Asked Questions
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