Dabigatran acyl-β-D-glucuronide

Dabigatran acyl-β-D-glucuronide is an active metabolite of the thrombin inhibitor Dabigatran (HY-10163) . Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma.

Product Specifications

CAS Number

[1015167-40-4]

UNSPSC

12352005

Target

Drug Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Smiles

CN1C2=CC=C(C=C2N=C1CNC3=CC=C(C=C3)C(N)=N)C(N(C4=NC=CC=C4)CCC(O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)C(O)=O)=O)=O

Molecular Formula

C31H33N7O9

Molecular Weight

647.64

References & Citations

[1]Eisert, W.G., Hauel, N., Stangier, J., et al. Dabigatran: An oral novel potent reversible nonpeptide inhibitor of thrombin. Arterioscler. Thromb. Vasc. Biol. 30 (10), 1885-1889 (2010) .|[2]Ebner, T., Wagner, K., and Wienen, W. Dabigatran acylglucuronide, the major human metabolite of dabigatran: In vitro formation, stability, and pharmacological activity. Drug. Metab. Dispos. 38 (9), 1567-1575 (2010) .