Dabigatran acyl-β-D-glucuronide
Dabigatran acyl-β-D-glucuronide is an active metabolite of the thrombin inhibitor Dabigatran. Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma.
Product Specifications
CAS Number
1015167-40-4
UNSPSC
12352005
Target
Drug Metabolite
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
CN1C2=CC=C(C=C2N=C1CNC3=CC=C(C=C3)C(N)=N)C(N(C4=NC=CC=C4)CCC(O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)C(O)=O)=O)=O
Molecular Formula
C31H33N7O9
Molecular Weight
647.64
References & Citations
[1]Eisert, W.G., Hauel, N., Stangier, J., et al. Dabigatran: An oral novel potent reversible nonpeptide inhibitor of thrombin. Arterioscler. Thromb. Vasc. Biol. 30 (10), 1885-1889 (2010) .|[2]Ebner, T., Wagner, K., and Wienen, W. Dabigatran acylglucuronide, the major human metabolite of dabigatran: In vitro formation, stability, and pharmacological activity. Drug. Metab. Dispos. 38 (9), 1567-1575 (2010) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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