Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Umbralisib (hydrochloride) (Standard)

Umbralisib (hydrochloride) (Standard) is the analytical standard of Umbralisib (hydrochloride) . This product is intended for research and analytical applications. Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseach[1][2][3][4].

Product Specifications

CAS Number

[1532533-78-0]

UNSPSC

12352100

Target

Casein Kinase; PI3K; Reference Standards

Related Pathways

Cell Cycle/DNA Damage; Others; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Cancer

Smiles

O=C1C(C2=CC=CC(F)=C2)=C([C@@H](N3N=C(C4=CC=C(OC(C)C)C(F)=C4)C5=C(N)N=CN=C53)C)OC6=CC=C(F)C=C16.[H]Cl

Molecular Formula

C31H25ClF3N5O3

Molecular Weight

608.01

References & Citations

[1]Swaroop Vakkalankaa, et al. Inhibition of PI3Kδ kinase by a selective, small molecule inhibitor suppresses B-cell proliferation and leukemic cell growth.|[2]Deng C, et al. Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies. Blood. 2017 Jan 5;129 (1) :88-99|[3]Maharaj K, et al. The dual PI3Kδ/CK1ε inhibitor umbralisib exhibits unique immunomodulatory effects on CLL T cells. Blood Adv. 2020 Jul 14;4 (13) :3072-3084.|[4]Burris HA 3rd, et al. Umbralisib, a novel PI3Kδ and casein kinase-1ε inhibitor, in relapsed or refractory chronic lymphocytic leukaemia and lymphoma: an open-label, phase 1, dose-escalation, first-in-human study. Lancet Oncol. 2018 Apr;19 (4) :486-496.

Shipping Conditions

Room temperature

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-12279CR/

Scientific Category

Reference Standards

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MOL1A Antibody
E18-0730-1 50 µg - 50 µL

MOL1A Antibody

Ask
View Details
Recombinant Shigella dysenteriae serotype 1 Homoserine O-succinyltransferase (metA)
MBS1433103-01 0.02 mg (E-Coli)

Recombinant Shigella dysenteriae serotype 1 Homoserine O-succinyltransferase (metA)

Ask
View Details
Recombinant Shigella dysenteriae serotype 1 Homoserine O-succinyltransferase (metA)
MBS1433103-02 0.02 mg (Yeast)

Recombinant Shigella dysenteriae serotype 1 Homoserine O-succinyltransferase (metA)

Ask
View Details
Recombinant Shigella dysenteriae serotype 1 Homoserine O-succinyltransferase (metA)
MBS1433103-03 0.1 mg (E-Coli)

Recombinant Shigella dysenteriae serotype 1 Homoserine O-succinyltransferase (metA)

Ask
View Details
Recombinant Shigella dysenteriae serotype 1 Homoserine O-succinyltransferase (metA)
MBS1433103-04 0.1 mg (Yeast)

Recombinant Shigella dysenteriae serotype 1 Homoserine O-succinyltransferase (metA)

Ask
View Details
Recombinant Shigella dysenteriae serotype 1 Homoserine O-succinyltransferase (metA)
MBS1433103-05 0.02 mg (Baculovirus)

Recombinant Shigella dysenteriae serotype 1 Homoserine O-succinyltransferase (metA)

Ask
View Details