Retro-1
Retro-1 is a toxin inhibitor. Retro-1 blocks the retrograde transport of STxB to the trans-Golgi network/Golgi. Retro-1 inhibits the cytotoxic effects of Ricin, bacterial toxins Stx1 and Stx2. Retro-1 can also substantially enhance the effectiveness of antisense and splice switching oligonucleotides[1].
Product Specifications
CAS Number
313683-81-7
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C1NC2=CC=C(C=C2C(N(C1)C(CC)=O)C3=CC=CC=C3)Br
Molecular Formula
C18H17BrN2O2
Molecular Weight
373.24
References & Citations
[1]Stechmann B, et al. Inhibition of retrograde transport protects mice from lethal ricin challenge. Cell. 2010 Apr 16;141 (2) :231-42. |[2]Ming X, et al. The small molecule Retro-1 enhances the pharmacological actions of antisense and splice switching oligonucleotides. Nucleic Acids Res. 2013 Apr 1;41 (6) :3673-87.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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