Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

T-5224 (Standard)

T-5224 (Standard) is the analytical standard of T-5224. This product is intended for research and analytical applications. T-5224 is a transcription factor c-Fos/activator protein (AP) -1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription[1][2].

Product Specifications

CAS Number

530141-72-1

UNSPSC

12352100

Target

AP-1; MMP; Reference Standards

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Others

Field of Research

Others

Smiles

OC1=NOC2=CC(COC3=C(CCC(O)=O)C=C(C(C4=C(O)C=C(OC5CCCC5)C=C4)=O)C=C3)=CC=C21

Molecular Formula

C29H27NO8

Molecular Weight

517.53

References & Citations

[1]Makino H, et al. A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebraldisc degeneration and associated pain. Sci Rep. 2017 Dec 5;7 (1) :16983.|[2]Aikawa Y, et al. Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1. Nat Biotechnol. 2008 Jul;26 (7) :817-23.|[3]Kamide D, et al. Selective activator protein-1 inhibitor T-5224 prevents lymph node metastasis in an oral cancer model. Cancer Sci.?2016 May;107 (5) :666-73.|[4]Izuta S, et al. T-5224, a selective inhibitor of c-Fos/activator protein-1, attenuates lipopolysaccharide-induced liver injury in mice. Biotechnol Lett. 2012 Dec;34 (12) :2175-82.|[5]Uchihashi S, et al. Metabolism of the c-Fos/activator protein-1 inhibitor T-5224 by multiple human UDP-glucuronosyltransferase isoforms. Drug Metab Dispos. 2011 May;39 (5) :803-13.|[6]Miyazaki H, et al. The effects of a selective inhibitor of c-Fos/activator protein-1 on endotoxin-induced acute kidney injury in mice. BMC Nephrol. 2012 Nov 23;13:153.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Multiallergy Food
AL0105 4x 2.5 mL

Multiallergy Food

Sign In for Pricing
View Details
INDOL1 (IDO2) Mouse Monoclonal Antibody [Clone ID: OTI4H4]
CF806620 100 µg

INDOL1 (IDO2) Mouse Monoclonal Antibody [Clone ID: OTI4H4]

Sign In for Pricing
View Details
Fxyd1 (NM_052992) Mouse Tagged ORF Clone
MG200238 10 µg

Fxyd1 (NM_052992) Mouse Tagged ORF Clone

Sign In for Pricing
View Details
INA Polyclonal Antibody
E-AB-15999-01 20 µL

INA Polyclonal Antibody

Sign In for Pricing
View Details
INA Polyclonal Antibody
E-AB-15999-02 60 µL

INA Polyclonal Antibody

Sign In for Pricing
View Details
INA Polyclonal Antibody
E-AB-15999-03 120 µL

INA Polyclonal Antibody

Sign In for Pricing
View Details