UC-773587
UC-773587 is a selective SOS1 catalytic activity inhibitor. UC-773587 binds to the catalytic site of Sos1 over HRas and ITSN (a RhoGEF) and inhibits nucleotide exchange with an IC50 value of 4.5 μM. UC-773587 mappes to the Ras switch II interaction region of the Sos1 catalytic site. UC-773587 can be used for the study of prostate cancer[1][2].
Product Specifications
CAS Number
116679-70-0
UNSPSC
12352005
Target
SOS1
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer
Smiles
OC(C=CC1=C2O3)=CC1=CC=C2C(C4=CC=CC=C4C([O-])=O)=C5C3=C6C=CC(C=C6C=C5)=O
Molecular Formula
C28H15O5
Molecular Weight
431.42
References & Citations
[1]Evelyn CR, et al. Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. J Biol Chem. 2015 May 15;290 (20) :12879-98. |[2]Gray JL, et al. Targeting the Small GTPase Superfamily through Their Regulatory Proteins. Angew Chem Int Ed Engl. 2020 Apr 16;59 (16) :6342-6366.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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