MitoBloCK-1

MitoBloCK-1 is an inhibitor that blocks the import of substrates that use the TIM22 import pathway. MitoBloCK-1 inhibits import by preventing binding of substrate to tim9/10 complex to the substrate, thus the substrate failed to be reach the TIM22 translocon. MitoBloCK-1 inhibits protein import of TIM22 substrates into mitochondria. MitoBloCK-1 attenuates the import of the carrier proteins including the ADP/ATP and phosphate carriers. MitoBloCK-1 also inhibits the import of an additional carrier protein, PiC, and the outer membrane protein Tom40[1][2].

Product Specifications

CAS Number

[373370-73-1]

Product Name Alternative

MB-1

UNSPSC

12352005

Target

Mitochondrial Metabolism

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Purity

98.87

Smiles

S=C(N/N=C/C1=C2C(CCCC3)=C3OC2=CC(Br)=C1O)N

Molecular Formula

C14H14BrN3O2S

Molecular Weight

368.25

References & Citations

[1]Wijaya J. Utilizing Small Molecules to Study Mitochondrial Presequence-Degrading Protease. UCLA, 2015.|[2]Hasson SA, et al. Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation. Proc Natl Acad Sci U S A. 2010 May 25;107 (21) :9578-83.