NPD13668
NPD13668 is an EZH2-mediated gene silencing modulator. NPD13668 inhibits EZH2/PRC2 (polycomb repressive complex 2) activity. NPD13668 reactivates the expression of silenced H3K27me3 target genes together with depletion of the H3K27me3 modification. NPD13668 can be used for the study of prostate cancer and ovarian cancer[1].
Product Specifications
CAS Number
864819-54-5
UNSPSC
12352005
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
O=C(NCCC1=CNC2=C1C=CC=C2)CC3=C(C)C4=CC=C(O)C(O)=C4OC3=O
Molecular Formula
C22H20N2O5
Molecular Weight
392.40
References & Citations
[1]Murashima A, et al. Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay. J Biochem. 2019 Jul 1;166 (1) :41-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EZH2
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb1975208 100 µL
Phospho-PDPK1 (Ser393) Rabbit Polyclonal Antibody (BF488)
Sign In for Pricing
View Details orb3010702-01 20 µg
Recombinant Human Micropeptide inhibiting actin cytoskeleton (MIAC)
Sign In for Pricing
View Details orb3010702-02 100 µg
Recombinant Human Micropeptide inhibiting actin cytoskeleton (MIAC)
Sign In for Pricing
View Details orb3010702-03 1 mg
Recombinant Human Micropeptide inhibiting actin cytoskeleton (MIAC)
Sign In for Pricing
View Details 
MBS6246548-01 0.1 mL
Myelin Associated Glycoprotein (MAG) (MaxLight 650)
Sign In for Pricing
View Details