NPD13668
NPD13668 is an EZH2-mediated gene silencing modulator. NPD13668 inhibits EZH2/PRC2 (polycomb repressive complex 2) activity. NPD13668 reactivates the expression of silenced H3K27me3 target genes together with depletion of the H3K27me3 modification. NPD13668 can be used for the study of prostate cancer and ovarian cancer[1].
Product Specifications
CAS Number
[864819-54-5]
UNSPSC
12352005
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
O=C(NCCC1=CNC2=C1C=CC=C2)CC3=C(C)C4=CC=C(O)C(O)=C4OC3=O
Molecular Formula
C22H20N2O5
Molecular Weight
392.40
References & Citations
[1]Murashima A, et al. Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay. J Biochem. 2019 Jul 1;166 (1) :41-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EZH2
Curated Selection
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