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DPA-714 (Standard)

DPA-714 (Standard) is the analytical standard of DPA-714. This product is intended for research and analytical applications. DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. 18FDPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model[1][2].

Product Specifications

CAS Number

958233-07-3

UNSPSC

12352100

Target

Mitochondrial Metabolism; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C(N(CC)CC)CC1=C2N=C(C)C=C(C)N2N=C1C3=CC=C(OCCF)C=C3

Molecular Formula

C22H27FN4O2

Molecular Weight

398.47

References & Citations

[1]James ML, et al. DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization. J Nucl Med. 2008 May;49 (5) :814-22.|[2]Harhausen D, et al. Specific imaging of inflammation with the 18 kDa translocator protein ligand DPA-714 in animal models of epilepsy and stroke. PLoS One. 2013 Aug 2;8 (8) :e69529.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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