D-G23
D-G23 is a selective RAD52 inhibitor. D-G23 disrupts RAD52-mediated DNA repair pathways and suppresses the growth of BRCA1- and BRCA2-deficient cancer cells. D-G23 is promising for research of homologous recombination-related cancers, such as hereditary breast cancer and ovarian cancer caused by BRCA1/2 mutations[1].
Product Specifications
CAS Number
[1225141-73-0]
UNSPSC
12352005
Target
RAD51
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
OCCCNC1=C2C=CC=CC2=NC(NC3=CC(OC)=CC=C3OC)=N1
Molecular Formula
C19H22N4O3
Molecular Weight
354.40
References & Citations
[1]Huang F, et al. Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors. Nucleic Acids Res. 2016 May 19;44 (9) :4189-99.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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