VHL Ligand 38

VHL Ligand 38 (Compound 1) is a competitive E3 ubiquitin-protein ligase VHL inhibitor with IC50s of 4.1 and 7.0 μM in 1% and 10% DMSO, respectively. VHL Ligand 38 contains a hydroxyproline residue and an isoxazolylacetamide fragment. VHL Ligand 38 significantly inhibits the binding of a fluorescent peptide derived from HIF1α (FAM-DEALA-Hyp-YIPD) (HY-P5908F) to VHL[1].

Product Specifications

CAS Number

[1360616-29-0]

UNSPSC

12352005

Target

E1/E2/E3 Enzyme

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Smiles

O=C([C@H]1N(C(CC2=CC(C)=NO2)=O)C[C@H](O)C1)NCC3=CC=C(C4=CN=CO4)C=C3

Molecular Formula

C21H22N4O5

Molecular Weight

410.42

References & Citations

[1]Buckley DL, et al. Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1α. Angew Chem Int Ed Engl. 2012 Nov 12;51 (46) :11463-7.