AM432 (sodium)

AM432 (sodium) is a potent and selective antagonist of the DP2 receptor (CRTH2) . AM432 (sodium) exhibits excellent potency in a human whole blood eosinophil shape change assay with prolonged incubation. AM432 (sodium) also demonstrates excellent pharmacokinetics in dog and mouse models of inflammatory disease[1].

Product Specifications

CAS Number

[1263409-34-2]

UNSPSC

12352005

Target

Prostaglandin Receptor

Related Pathways

GPCR/G Protein

Field of Research

Neurological Disease

Smiles

O=C(O[Na])CC1=CC(C2=CC=C(C3=CC=C(OCC)N=C3)C=C2CN(C(C4CC4)=O)CC)=C(OC)C=C1

Molecular Formula

C29H31N2NaO5

Molecular Weight

510.56

References & Citations

[1]Nicholas Stock, et al., Sodium [2′-[ (cyclopropanecarbonyl-ethyl-amino) -methyl]-4′- (6-ethoxy-pyridin-3-yl) -6-methoxy-biphenyl-3-yl]-acetate (AM432) : A potent, selective prostaglandin D2 receptor antagonist, 2011, 21 (3) : 1036-1040.