Butropium (bromide)

Butropium bromide is a competitive mAChR antagonist. Butropium bromide blocks acetylcholine-mediated glandular secretion and muscle contraction signals, suppressing salivary gland secretion and respiratory smooth muscle spasms. Butropium bromide is promising for research of excessive salivation[1][2].

Product Specifications

CAS Number

[29025-14-7]

UNSPSC

12352005

Target

MAChR

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Endocrinology

Smiles

[H][C@]12C[C@H](C[C@]([N+]2(C)CC3=CC=C(C=C3)OCCCC)([H])CC1)OC(C(CO)C4=CC=CC=C4)=O.[Br-]

Molecular Formula

C28H38BrNO4

Molecular Weight

532.51

References & Citations

[1]Sakamoto Y, et al. The Effect of Butropium Bromide as a Premedication for Depression of Salivation on Endoscopic Examination Using Double Blind Technique[J]. Nihon Kikan Shokudoka Gakkai Kaiho, 1977, 28 (1) : 20-24.|[2]Chiba S. Effect of N- (4-butoxybenzyl) hyoscyaminium bromide (butropium bromide) on the isolated, blood-perfused canine atrium preparation[J]. Japanese Heart Journal, 1980, 21 (5) : 753-759.