OSU-03013
OSU-03013 is a Celecoxib (HY-14398) analog. OSU-03013 can promote apoptosis, up-regulate E-cadherin, and down-regulate β-catenin, c-myc, Wnt1, and N-cadherin. OSU-03013 reduces cell migration and invasion. OSU-03013 regulates both Wnt and mTOR expression to inhibit colon cancer (CC) cell proliferation. OSU-03013 can be used for CC cancer research[1].
Product Specifications
CAS Number
[742112-34-1]
UNSPSC
12352005
Target
Apoptosis; Cadherin; c-Myc; mTOR; Wnt; β-catenin
Related Pathways
Apoptosis; Cytoskeleton; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Cancer
Smiles
NC(NC1=CC=C(N2N=C(C(F)(F)F)C=C2C3=CC=C4C5=CC=CC=C5C=CC4=C3)C=C1)=N
Molecular Formula
C25H18F3N5
Molecular Weight
445.44
References & Citations
[1]Chunyong Y, et al. Mechanism of Inhibition of Growth and Metastasis of Colon Cancer by Celecoxib Analog OSU-03013 via Wnt Signaling Pathway. Acta Poloniae Pharmaceutica – Drug Research. 2023, 80 (6) : 929-937.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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