Bis (2R,3R) -Orniplabin

Bis (2R,3R) -Orniplabin is an isomer of Orniplabin (HY-122311) . Orniplabin (SMTP-7) is a low molecular weight compound that enhances plasminogen-fibrin binding, urokinase-catalyzed plasminogen activation, and urokinase and plasminogen-mediated fibrin degradation. Orniplabin exhibits potential thrombolytic and anti-inflammatory effects. Orniplabin inhibits reactive oxygen species (ROS) [1][2].

Product Specifications

Product Name Alternative

Bis (2R,3R) -SMTP-7

UNSPSC

12352005

Target

Drug Isomer

Related Pathways

Others

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Purity

95.0

Smiles

O=C1C2=C(C3=C(C[C@@H](O)[C@](CC/C=C(C)/CC/C=C(C)/C)(C)O3)C(O)=C2)CN1[C@H](C(O)=O)CCCN4CC5=C(C=C(O)C6=C5O[C@@](CC/C=C(C)/CC/C=C(C)/C)(C)[C@H](O)C6)C4=O

Molecular Formula

C51H68N2O10

Molecular Weight

869.09

References & Citations

[1]Shibata K, et al. A novel finding of a low-molecular-weight compound, SMTP-7, having thrombolytic and anti-inflammatory effects in cerebral infarction of mice. Naunyn Schmiedebergs Arch Pharmacol. 2010 Sep;382 (3) :245-53. |[2]Shibata K, et al. Neuroprotective mechanisms of SMTP-7 in cerebral infarction model in mice. Naunyn Schmiedebergs Arch Pharmacol. 2011 Jul;384 (1) :103-8.