SB 414240

SB 414240 is a selective neurokinin-2 receptor (NK-2R) antagonist with Kis of 1 nM and 193 nM for human NK-3R and human NK-2R, respectively. SB 414240 does not bind the human μ-opioid receptor (hMOR) . SB 414240 can be used for the study of neurological disease[1].

Product Specifications

CAS Number

[272104-60-6]

UNSPSC

12352005

Target

Neurokinin Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(N[C@@H](C)C(C)(C)C)C1=C(C(C2=CC=CC=C2)=NC3=CC=CC=C13)CN4CCC(CC4)N5CCCCC5

Molecular Formula

C33H44N4O

Molecular Weight

512.73

References & Citations

[1]Blaney FE, et al. Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity and selectivity in quinoline tachykinin receptor antagonists. J Med Chem. 2001 May 24;44 (11) :1675-89.