L-870812

L-870812 is a HIV-1 integration with integrase strand transfer inhibitor. L-870812 consistently blocks cell-free and cell-associated HIV-1 infection. L-870812 blocks subtype C and CRFO2_AG primary isolates. L-870812 can be used for the study of replication-deficient HIV-1 Ba-L (env) pseudovirus[1].

Product Specifications

CAS Number

[410545-90-3]

UNSPSC

12352005

Target

HIV Integrase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

O=C(N(C1=C2C=CC=NC2=C(O)C(C(NCC3=CC=C(F)C=C3)=O)=N1)C)C(N(C)C)=O

Molecular Formula

C21H20FN5O4

Molecular Weight

425.41

References & Citations

[1]Terrazas-Aranda K, et al. Human immunodeficiency virus type 1 (HIV-1) integration: a potential target for microbicides to prevent cell-free or cell-associated HIV-1 infection. Antimicrob Agents Chemother. 2008 Jul;52 (7) :2544-54.