SW43

SW43 is a Sigma-2 selective ligand and agonist. SW43 is an ideal molecule for the development of cancer-targeted drug compounds. SW43 conjugated with DOX-L-NETA (89Y) exhibits antitumor activity in a VX2 cancer liver tumor allograft rabbit model. SW 43 conjugated with SW IV-52s to form SW III-123 activates the NF-κB pathway, has potent cytotoxicity against ovarian cancer cell lines, and induces apoptosis[1][2].

Product Specifications

CAS Number

[1590379-85-3]

UNSPSC

12352005

Target

Sigma Receptor

Related Pathways

Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(NC1=CC(C)=CC=C1OC)OC2CC3N(C(C2)CCC3)CCCCCCCCCCN

Molecular Formula

C27H45N3O3

Molecular Weight

459.66

References & Citations

[1]Ludwig JM, et al. Targeted Yttrium 89-Doxorubicin Drug-Eluting Bead-A Safety and Feasibility Pilot Study in a Rabbit Liver Cancer Model. Mol Pharm. 2017 Aug 7;14 (8) :2824-2830.|[2]Zeng C, et al. Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer. Br J Cancer. 2013 Oct 29;109 (9) :2368-77.