NTRC-739

NTRC-739 is a selective nonpeptide partial neurotensin receptor type 2 (NTS2) agonist with an EC50 of 12 nM and a Ki of 153 nM. NTRC-739 is 161-fold selective for NTS2 versus NTS1. NTRC-739 can be used for the study of chronic pain research[1].

Product Specifications

CAS Number

[1612188-96-1]

UNSPSC

12352005

Target

Neurotensin Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C(C1(NC(C2=NN(C3=CC=C(F)C=C3)C(C4=CC=CC=C4OC)=C2)=O)CCCCC1)O

Molecular Formula

C24H24FN3O4

Molecular Weight

437.46

References & Citations

[1]Thomas JB, et al. Identification of 1- ({[1- (4-fluorophenyl) -5- (2-methoxyphenyl) -1H-pyrazol-3-yl]carbonyl}amino) cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound. J Med Chem. 2014 Jun 26;57 (12) :5318-32.