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Pyr-​Pro-​Arg-​pNA (hydrochloride)

Pyr-Pro-Arg-pNA (S2366) hydrochloride is a chromogenic peptide substrate for Factor XI and Activated protein C (APC) . Pyr-Pro-Arg-pNA hydrochloride can induce noncompetitive inhibition of factor XI activation through occupancy of the active site of the factor XIa-light chain. Pyr-Pro-Arg-pNA hydrochloride can be used for measurement of APC amidolytic activity[1][2].

Product Specifications

CAS Number

[127428-47-1]

Product Name Alternative

S-2366 (hydrochloride)

UNSPSC

12352211

Target

APC; Biochemical Assay Reagents; Factor XI

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Field of Research

Others

Smiles

O=C([C@@H]1CCC(N1)=O)N2[C@@H](CCC2)C(N[C@@H](CCCNC(N)=N)C(NC3=CC=C(C=C3)[N+]([O-])=O)=O)=O.Cl

Molecular Formula

C22H31ClN8O6

Molecular Weight

538.98

References & Citations

[1]Sinha D, et al. Macromolecular substrate-binding exosites on both the heavy and light chains of factor XIa mediate the formation of the Michaelis complex required for factor IX-activation. Biochemistry. 2007 Aug 28;46 (34) :9830-9. |[2]Berg DT, et al. Engineering the proteolytic specificity of activated protein C improves its pharmacological properties. Proc Natl Acad Sci U S A. 2003 Apr 15;100 (8) :4423-8.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Curated Selection

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