Pyr-Pro-Arg-pNA (hydrochloride)
Pyr-Pro-Arg-pNA (S2366) hydrochloride is a chromogenic peptide substrate for Factor XI and Activated protein C (APC) . Pyr-Pro-Arg-pNA hydrochloride can induce noncompetitive inhibition of factor XI activation through occupancy of the active site of the factor XIa-light chain. Pyr-Pro-Arg-pNA hydrochloride can be used for measurement of APC amidolytic activity[1][2].
Product Specifications
CAS Number
127428-47-1
Product Name Alternative
S-2366 (hydrochloride)
UNSPSC
12352211
Target
APC; Biochemical Assay Reagents; Factor XI
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others
Field of Research
Others
Smiles
O=C([C@@H]1CCC(N1)=O)N2[C@@H](CCC2)C(N[C@@H](CCCNC(N)=N)C(NC3=CC=C(C=C3)[N+]([O-])=O)=O)=O.Cl
Molecular Formula
C22H31ClN8O6
Molecular Weight
538.98
References & Citations
[1]Sinha D, et al. Macromolecular substrate-binding exosites on both the heavy and light chains of factor XIa mediate the formation of the Michaelis complex required for factor IX-activation. Biochemistry. 2007 Aug 28;46 (34) :9830-9. |[2]Berg DT, et al. Engineering the proteolytic specificity of activated protein C improves its pharmacological properties. Proc Natl Acad Sci U S A. 2003 Apr 15;100 (8) :4423-8.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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