SCH 2047069

SCH 2047069 (MK-8267) is an orally active kinesin spindle protein (KSP) inhibitor (Kd: 0.5 nM) that can cross the blood-brain barrier. SCH 2047069 exhibits an IC50 value of ≤ 5 nM against the KSP ATPase. SCH 2047069 exhibits broad-spectrum antitumor activity. SCH 2047069 can induce mitotic arrest and apoptosis in tumor cells. SCH 2047069 can be used in the research of tumors such as ovarian cancer, colon cancer, glioblastoma, and lymphoma[1][2].

Product Specifications

CAS Number

1146209-50-8

Product Name Alternative

MK-8267

UNSPSC

12352005

Target

Apoptosis; Kinesin

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Smiles

CC(N1N=C(C2=CC(F)=CC=C2F)S[C@@]31[C@H](CCN)COC4=CC(F)=C(F)C=C34)=O

Molecular Formula

C20H17F4N3O2S

Molecular Weight

439.43

References & Citations

[1]Basso AD, et al. SCH 2047069, a novel oral kinesin spindle protein inhibitor, shows single-agent antitumor activity and enhances the efficacy of chemotherapeutics. Mol Cancer Ther. 2010 Nov;9 (11) :2993-3002.|[2]Nyamaa B, et al. Kinesin spindle protein inhibition in translational research. Journal of Lipid and Atherosclerosis, 2014, 3 (2) : 63-78.