SCH 2047069
SCH 2047069 (MK-8267) is an orally active kinesin spindle protein (KSP) inhibitor (Kd: 0.5 nM) that can cross the blood-brain barrier. SCH 2047069 exhibits an IC50 value of ≤ 5 nM against the KSP ATPase. SCH 2047069 exhibits broad-spectrum antitumor activity. SCH 2047069 can induce mitotic arrest and apoptosis in tumor cells. SCH 2047069 can be used in the research of tumors such as ovarian cancer, colon cancer, glioblastoma, and lymphoma[1][2].
Product Specifications
CAS Number
1146209-50-8
Product Name Alternative
MK-8267
UNSPSC
12352005
Target
Apoptosis; Kinesin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Smiles
CC(N1N=C(C2=CC(F)=CC=C2F)S[C@@]31[C@H](CCN)COC4=CC(F)=C(F)C=C34)=O
Molecular Formula
C20H17F4N3O2S
Molecular Weight
439.43
References & Citations
[1]Basso AD, et al. SCH 2047069, a novel oral kinesin spindle protein inhibitor, shows single-agent antitumor activity and enhances the efficacy of chemotherapeutics. Mol Cancer Ther. 2010 Nov;9 (11) :2993-3002.|[2]Nyamaa B, et al. Kinesin spindle protein inhibition in translational research. Journal of Lipid and Atherosclerosis, 2014, 3 (2) : 63-78.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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