FJ-5002
FJ-5002 is a telomerase inhibitor with an IC50 of 2 μM. FJ-5002 can induce telomere shortening, increased chromosomal abnormalities, and senescence/crisis-like features in the human leukemia cell line U937. FJ-5002 exhibits antitumor activity and can be used in the study of cancer[1][2].
Product Specifications
CAS Number
247129-77-7
UNSPSC
12352005
Target
Telomerase
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
CC1=CSC(/C=C(N(CC)C/2=O)\SC2=C3SC4=CC=CC=C4N\3C)=[N+]1CC.[Cl-]
Molecular Formula
C20H22ClN3OS3
Molecular Weight
452.06
References & Citations
[1]Guo WZ, et al. Search for novel anti-tumor agents from ridaifens using JFCR39, a panel of human cancer cell lines. Biol Pharm Bull. 2013;36 (6) :1008-16.|[2]Naasani I, et al FJ5002: a potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis. Cancer Res. 1999 Aug 15;59 (16) :4004-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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