FJ-5002
FJ-5002 is a telomerase inhibitor with an IC50 of 2 μM. FJ-5002 can induce telomere shortening, increased chromosomal abnormalities, and senescence/crisis-like features in the human leukemia cell line U937. FJ-5002 exhibits antitumor activity and can be used in the study of cancer[1][2].
Product Specifications
CAS Number
247129-77-7
UNSPSC
12352005
Target
Telomerase
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
CC1=CSC(/C=C(N(CC)C/2=O)\SC2=C3SC4=CC=CC=C4N\3C)=[N+]1CC.[Cl-]
Molecular Formula
C20H22ClN3OS3
Molecular Weight
452.06
References & Citations
[1]Guo WZ, et al. Search for novel anti-tumor agents from ridaifens using JFCR39, a panel of human cancer cell lines. Biol Pharm Bull. 2013;36 (6) :1008-16.|[2]Naasani I, et al FJ5002: a potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis. Cancer Res. 1999 Aug 15;59 (16) :4004-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LY434003 100 µg
RhoGDI (ARHGDIA) (NM_001185078) Human Over-expression Lysate
Sign In for Pricing
View Details