FJ-5002

FJ-5002 is a telomerase inhibitor with an IC50 of 2 μM. FJ-5002 can induce telomere shortening, increased chromosomal abnormalities, and senescence/crisis-like features in the human leukemia cell line U937. FJ-5002 exhibits antitumor activity and can be used in the study of cancer[1][2].

Product Specifications

CAS Number

[247129-77-7]

UNSPSC

12352005

Target

Telomerase

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

CC1=CSC(/C=C(N(CC)C/2=O)\SC2=C3SC4=CC=CC=C4N\3C)=[N+]1CC.[Cl-]

Molecular Formula

C20H22ClN3OS3

Molecular Weight

452.06

References & Citations

[1]Guo WZ, et al. Search for novel anti-tumor agents from ridaifens using JFCR39, a panel of human cancer cell lines. Biol Pharm Bull. 2013;36 (6) :1008-16.|[2]Naasani I, et al FJ5002: a potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis. Cancer Res. 1999 Aug 15;59 (16) :4004-11.