NSC177365
NSC177365 (NSC 1) is a CcrM inhibitor. NSC177365 is a competitive DNA inhibitor and disrupts DNA binding. NSC177365 has antibacterial activity, with IC50s of 2.3 and 14.6 μM for C. crescentus and M. lincolnii respectively. NSC177365 reverses several neurodegenerative disorders and serve as an anticancer agent[1].
Product Specifications
CAS Number
[80261-18-3]
Product Name Alternative
NSC 1
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Cancer; Infection; Neurological Disease
Smiles
O=S(CCCNC(N)=N)(NC1=CC=C(NC2=C(C=CC([N+]([O-])=O)=C3)C3=NC4=CC=CC=C42)C=C1)=O
Molecular Formula
C23H23N7O4S
Molecular Weight
493.54
References & Citations
[1]Hernandez I, et al. Allosteric Inhibitors of Cell-Cycle-Regulated Methyltransferase for Novel Antibiotic Development. ACS Omega. 2025 Apr 9;10 (15) :15775-15780.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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