A-423579
A-423579 is an orally active non-imidazole histamine H3 receptor antagonist. A-423579 exhibits high affinity and good selectivity for human and rat H3 receptors, and possesses both antagonistic and inverse agonistic activities. A-423579 can effectively reduce body weight in obese rodents, with concomitant decreases in fat content, plasma leptin levels, and triglycerides. A-423579 possesses anti-obesity activity and can be used in the research of obesity and related metabolic disorders[1][2].
Product Specifications
CAS Number
461045-17-0
UNSPSC
12352005
Target
Histamine Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Metabolic Disease
Smiles
CN([C@@H]1CCN(CCCOC2=C(F)C=C(C3=CC=C(C#N)C=C3)C=C2F)C1)C
Molecular Formula
C22H25F2N3O
Molecular Weight
385.45
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H3 Receptor
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Rabbit Anti-Human IgG gamma chain - Alexa Fluor 488
