ML309
ML309 is a highly selective and potent inhibitor of the R132H mutant isocitrate dehydrogenase 1 (IDH1 R132H), with an IC50 of 96 nM. ML309 is a competitive inhibitor of α-KG, with a Ki value of 156 nM, and its inhibitory activity against the wild-type IDH1 is greater than 35 μM. ML309 effectively reduces the production of the tumor metabolite 2-HG in U87MG cells. ML309 can be used as a chemical probe to study the role of the mutant IDH1 in cancer[1].
Product Specifications
CAS Number
1355446-05-7
UNSPSC
12352005
Target
Isocitrate Dehydrogenase (IDH)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(N(C(C1=CC=CC=C1C)C(NC2CCCC2)=O)C3=CC=CC(F)=C3)CN4C5=CC=CC=C5N=C4
Molecular Formula
C29H29FN4O2
Molecular Weight
484.56
References & Citations
[1]Davis M, et al. ML309: A potent inhibitor of R132H mutant IDH1 capable of reducing 2-hydroxyglutarate production in U87 MG glioblastoma cells. 2012 Apr 16 [updated 2013 May 8]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD) : National Center for Biotechnology Information (US) ; 2010–.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDH1
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
CVSOLN011 100 mL
Crystal Violet Indicator 0.1% (w/v) in Glacial Acetic A - 100ML
Sign In for Pricing
View Details 
032433-HRP 200 µL
BATF2, NT (BATF2, Basic leucine zipper transcriptional factor ATF-like 2, Suppressor of AP-1 regulated by IFN) (Azide free) (HRP) discontinued
Sign In for Pricing
View Details