TDI-2760
TDI-2760 is an Aβ aggregation inhibitor with an IC50 of 1.67 μM. TDI-2760 can inhibit the Aβ-fibrinogen interaction and Aβ aggregation, and also modulate the contact system activation induced by Aβ42. TDI-2760 can be used in research related to vascular abnormalities and Aβ aggregation in Alzheimer's disease[1].
Product Specifications
CAS Number
[956128-08-8]
UNSPSC
12352005
Target
Amyloid-β
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CN(C1=CC(OC2=CN=C(NC3=CC=CC=C3)N=C2)=CC=C1)C
Molecular Formula
C18H18N4O
Molecular Weight
306.36
References & Citations
[1]Singh PK, et al. Aminopyrimidine Class Aggregation Inhibitor Effectively Blocks Aβ-Fibrinogen Interaction and Aβ-Induced Contact System Activation. Biochemistry. 2018 Feb 27;57 (8) :1399-1409.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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