R-116010
R-116010 is a potent and selective retinoic acid (RA) metabolism inhibitor and can inhibit hydroxylase CYP26. R-116010 can enhance the anti-tumor effect of retinoic acid drugs. R-116010 can be used for the research of cancer, metabolic and neurological disease, such as neuroblastoma[1].
Product Specifications
CAS Number
355860-40-1
UNSPSC
12352005
Target
Cytochrome P450; RAR/RXR
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Smiles
C[C@H](N(C)C)[C@H](C1=CC=C(NC2=NC3=CC=CC=C3S2)C=C1)N4C=CN=C4
Molecular Formula
C21H23N5S
Molecular Weight
377.51
References & Citations
[1]Armstrong JL, et al. Increasing the intracellular availability of all-trans retinoic acid in neuroblastoma cells. Br J Cancer. 2005 Feb 28;92 (4) :696-704.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP26
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