CP-99994

CP-99994 is a Tachykinin neurokinin 1 (NK-1) receptor antagonist with a Ki of 0.25 nM. CP-99994 prevents colorectal sensitization in the context of visceral hypersensitivity. CP-99994 reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity[1].

Product Specifications

CAS Number

[136982-36-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Neurokinin Receptor; p38 MAPK

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

COC(C=CC=C1)=C1CN[C@@H]2[C@H](C3=CC=CC=C3)NCCC2

Molecular Formula

C19H24N2O

Molecular Weight

296.41

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]McLean S, et al. Pharmacology of CP-99,994; a nonpeptide antagonist of the tachykinin neurokinin-1 receptor. J Pharmacol Exp Ther. 1993 Oct;267 (1) :472-9.