CP-99994
CP-99994 is a Tachykinin neurokinin 1 (NK-1) receptor antagonist with a Ki of 0.25 nM. CP-99994 prevents colorectal sensitization in the context of visceral hypersensitivity. CP-99994 reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity[1].
Product Specifications
CAS Number
[136982-36-0]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Neurokinin Receptor; p38 MAPK
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
COC(C=CC=C1)=C1CN[C@@H]2[C@H](C3=CC=CC=C3)NCCC2
Molecular Formula
C19H24N2O
Molecular Weight
296.41
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
NK1R
Available Sizes
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