N-Deacetylcolchicine (tartrate)
N-Deacetylcolchicine tartrate is a microtubule polymerization inhibitor with an IC50 of 3 μM against bovine brain microtubules. N-Deacetylcolchicine tartrate is a derivative of Colchicine. N-Deacetylcolchicine tartrate can activate the GTPase activity of microtubules and can be used for the research of cancer[1][2].
Product Specifications
CAS Number
49720-72-1
UNSPSC
12352005
Target
Arf Family GTPase; Drug Derivative; Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; GPCR/G Protein; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
OC([C@H](O)[C@@H](O)C(O)=O)=O.O=C1C=C2[C@@H](N)CCC3=CC(OC)=C(OC)C(OC)=C3C2=CC=C1OC
Molecular Formula
C24H29NO11
Molecular Weight
507.49
References & Citations
[1]Muzaffar, A., et al. Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids. J. Med. Chem. 33 (2), 567-571 (1990) .|[2]Lin, et al. Effects of inhibitors of tubulin polymerization on GTP hydrolysis. The Journal of Biological Chemisty 256 (17), 9242-9245 (1981) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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